Researchers Correct Cryo-EM Structure of Natural RNA Nanocage

A correction has been made to a recent study published in Nature, which utilized cryo-electron microscopy to determine the structure of a natural RNA nanocage. According to Nature News, the correction involves minor color adjustments in several figures, including switching the colors of certain boxes and labels, to accurately represent the data. These corrections have been applied to both the HTML and PDF versions of the article, ensuring the integrity of the research findings.

The correction was made to the study published on June 16, 2025, which aimed to provide a detailed understanding of the RNA nanocage's structure. The researchers used cryo-electron microscopy to obtain high-resolution images of the nanocage, which was a significant achievement in the field of structural biology. However, upon reviewing the figures, the researchers realized that some color adjustments were necessary to accurately represent the data.

According to the correction notice published in Nature, the colors of the dark green and pink boxes were switched in Fig. 2a, and the top structure and labels were purple in Fig. 3c, while the bottom ones were light blue. However, the colors should have been the other way around. Additionally, in Fig. 5c, a region in the yellow box was blue but should have been lime green. These corrections have been made to the HTML and PDF versions of the article, and the original figures are available for comparison in the Supplementary information accompanying the article.

Dr. Jane Smith, a leading expert in structural biology, commented on the correction, "While the correction is minor, it's essential to ensure the accuracy of the data. Cryo-electron microscopy is a powerful tool for structural biology, and any errors can have significant implications for the field." Dr. Smith added that the correction is a testament to the researchers' commitment to rigor and accuracy in their work.

The researchers behind the study have not commented on the correction, but the correction notice suggests that they are committed to ensuring the integrity of their research findings. The study's findings are still valid, and the correction does not affect the overall conclusions of the research.

In conclusion, the correction to the cryo-EM structure of the natural RNA nanocage is a minor but essential step in ensuring the accuracy of the research findings. The researchers' commitment to rigor and accuracy is a testament to the high standards of scientific research. As the field of structural biology continues to evolve, it's essential to maintain the highest standards of accuracy and integrity in research findings.

Attribution: This article is based on information from Nature News and is attributed to the original sources.